(+/-) 2-Imidazol-1-ylsuccinic acid disodium salt
ISUCA was our second pHe probe, improving some pharmacological and technical aspects aspects of the previous probe IEPA, as blood retention time and increased pH resolution. Our results in vivo, revealed no signiﬁcant correlation between extracellular pH and the lactate resonance, indicating that either protons diffuse faster than lactate from the lactate production sites or, that tumors present additional sources of protons to lactate.
Provent P, Benito M, Hilba B, et al. Serial in vivo spectroscopic NMR imaging of lactate and extracellular pH in rat 1gliomas shows redistribution of protons away from sites of glycolysis. Cancer Res 2007;67:7638–45.