Timeline

2011 - present
Soirem Research: Start as a biotech company.
2010
The Perspective: “Environmentally Sensitive Paramagnetic and Diamagnetic Contrast Agents for Nuclear Magnetic Resonance Imaging and Spectroscopy” Pacheco-Torres J., Calle D, Lizarbe B, Negri V, Ubide C, Fayos R, Lopez Larrubia P, Ballesteros P, Cerdan S. Current Topics in Medicinal Chemistry 12/2010; 11(1):115-130.
2007
In vivo application of second PHe Probe: “Serial in vivo nuclear magnetic resonance imaging of lactate and extracellular pH in rat gliomas shows redistribution of protons away from sites of glycolysis” Provent P, Benito M, Hiba B, Flarion R, López-Larrubia P, Ballesteros P, Rémy C, Segebarth C, Cerdán S, Coles JA, García-Martín ML. Cancer Research, 2007 67(16):7638-45.
2001
In vivo application of first pHe Probe: “Mapping Extracellular pH in Rat Brain Gliomas in Vivo by 1H Magnetic Resonance Spectroscopic Imaging: Comparison with Maps of Metabolites1”   Herigault G, Remy C, Flarion R, Ballesteros P, Coles JA, Cerdan S, Ziegler A. Cancer Research 09/2001; 61(17).
1994-1996

1996 The basic chemistry of pHe and pO2 probes: “Addition of Azoles and Amines to Unsymmetrical Fumaric Esters” Zaderenko P, López MC, Ballesteros P. The Journal of Organic Chemistry 11/1996; 61(20):6825-6828.

1994 The first generation of pHe probes: “Imidazol-1-ylalkanoic acids as extrinsic 1H NMR probes for the determination of intracellular pH, extracellular pH and cell volume ” Gil S, Zaderenko P, Cruz F, Cerdan S, Ballesteros P. Bioorg. Med. Chem. 1994 2(5):305-14.